Cetilistat CAS Naj Npawb: 282526-98-1 Molecular Formula: C25H39NO3
| Melting Point | 72.0 txog 76.0 ° C |
| Qhov ntom | 1.02 ib |
| cia temp | Muab ntim rau hauv qhuav, 2-8 ° C |
| solubility | Chloroform (me ntsis), Ethyl Acetate (me ntsis) |
| kev ua haujlwm kho qhov muag | N/A |
| Qhov tshwm sim | Off-dawb Cryst |
| Purity | ≥98% |
Cetilistat (tseem hu ua ATL-962) tau pom zoo nyob rau lub Cuaj Hli 2013 los ntawm Nyiv Ministry of Health, Labor thiab Welfare rau kev kho mob rog, txwv rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus (T2DM) thiab dyslipidemia, thiab nrog lub cev loj. Index (BMI) 25 kg/m2Txawm tias muaj kev noj haus thiab / lossis kev kho mob qoj ib ce.Raws li nrog orlistat, cetilistat ua haujlwm los ntawm inhibition ntawm pancreatic lipases hauv plab txhawm rau tiv thaiv kev nqus rog thiab yog li txo qis caloric los ntawm kev noj zaub mov.Cov kev pabcuam tshuaj chemistry tsis tau piav qhia hauv cov ntaub ntawv tshawb fawb, tab sis patent piav qhia txog cetilistat kuj piav qhia txog kev sib xyaw ntawm cov analogs nrog ntau yam aryl substituents thiab lipophilic tails.Lub synthesis ntawm cetilistat suav nrog condensation ntawm hexadecylcarbonochloridate nrog 2-amino-5-methylbenzoic acid;Lwm cov analogues tau tsim los ntawm kev sib txawv ntawm carbonochloridate thiab 2-aminobenzoic acid Cheebtsam.Cetilistat yog ib qho muaj zog inhibitor ntawm tib neeg thiab nas pancreatic lipase nrog IC50s ibntawm 15 thiab 136 nM, feem, nrog me ntsis inhibition ntawm trypsin lossis chymotrypsin.
Ib qho tshiab pancreatic lipase inhibitor rau kev kho mob rog rog hauv ob tus neeg mob ntshav qab zib thiab tsis yog ntshav qab zib.
Nug tus kws kho mob ua ntej
