CAS Naj Npawb: 54-31-9 Molecular Formula: C12H11ClN2O5S
| Melting Point | 261-263 ° C |
| Qhov ntom | 1.16 (zeeg) |
| cia temp | Inert cua, Chav Kub Kub 2-8 ° C |
| solubility | DMSO:> 5 mg / mL ntawm 60 ° C |
| kev ua haujlwm kho qhov muag | N/A |
| Qhov tshwm sim | Off-White Solid |
| Purity | ≥98% |
Telmisartan tau tsim tawm hauv Asmeskas rau kev kho mob ntshav siab.Nws tuaj yeem npaj tau yim theem pib nrog methyl 4-amino-3-methyl benzoate;thawj thiab thib ob cyclization rau hauv lub nplhaib benzimidazole tshwm sim ntawm qib 4 thiab 6 raws li.Telmisartan thaiv qhov kev txiav txim ntawm angiotensin II (Ang II), thawj cov nyhuv molecule ntawm renin-angiotensin-aldosterone system (RAAS).Nws yog thib rau ntawm chav kawm ntawm 'sartans' yuav tsum tau ua lag luam tom qab cov hlau lead compound Losartan.Nws cov nyhuv ntev ntev (24h ib nrab-lub neej) tuaj yeem yog qhov sib txawv tseem ceeb nrog rau lwm cov angiotensin II antagonists.Tsis zoo li ntau lwm tus neeg ua haujlwm hauv pawg no, nws cov haujlwm tsis yog nyob ntawm kev hloov pauv mus rau hauv cov metabolite nquag, 1-O-acylglucuronide yog cov metabolite tseem ceeb hauv tib neeg.Telmisartan yog lub zog sib tw antagonist ntawm AT1 receptors uas kho feem ntau ntawm cov teebmeem tseem ceeb ntawm angiotensin II thaum tsis muaj kev sib raug zoo rau AT2 subtypes lossis lwm yam receptors koom nrog hauv kev tswj hwm plawv.Hauv ntau qhov kev tshawb fawb soj ntsuam, Telmisartan, ib zaug ib hnub noj, ua rau muaj txiaj ntsig zoo thiab ua kom cov ntshav siab txo qis nrog qhov tshwm sim tsis tshua muaj tshwm sim (tshwj xeeb yog kev kho mob hnoos nrog ACE inhibitors hauv cov neeg laus).
Telmisartan yog angiotensin II receptor antagonist.
