CAS Naj Npawb: 146-56-5 Molecular Formula: C20H21ClN2O4
| Melting Point | 176-178 ° C |
| Qhov ntom | 1.02 g / cm³ |
| cia temp | rub ntawm chav tsev kub, tawm ntawm tshav ntuj ncaj qha thiab nyob rau hauv ib qho chaw ntub dej |
| solubility | 50 mg / ml (hauv ethanol);Insoluble hauv dej |
| kev ua haujlwm kho qhov muag | +111.6 degrees (C = 1, methanol) |
| Qhov tshwm sim | dawb los yog yuav luag dawb crystalline hmoov |
| Purity | ≥97% |
yog "dihydropyridine calcium antagonist" (calcium antagonist, los yog qeeb channel blocker) uas inhibits lub zog ntawm "calcium ions" mus rau vascular du leeg hlwb thiab plawv myocytes.Cov ntaub ntawv sim qhia tias muaj feem xyuam nrog "cov chaw sib txuas" rau "dihydropyridines" thiab "non-dihydropyridines".Ob lub plawv thiab vascular du nqaij 'cov txheej txheem sib cog lus' nyob ntawm qhov nkag ntawm 'extracellular calcium ions' rau hauv cov hlwb ntawm cov ion tshwj xeeb.xaiv inhibits qhov ntws ntawm calcium ions hla cov cell membranes, ib qho kev cuam tshuam rau vascular du leeg hlwb ntau dua li cov hlwb.Cov nyhuv tsis zoo inotropic (Inotrope), lossis txo qis hauv myocardial contractility, tuaj yeem kuaj pom hauv vitro.Txawm li cas los xij, cov txiaj ntsig zoo li no tsis tau pom nyob rau hauv cov tsiaj uas tau tswj hwm hauv cov tshuaj kho mob.Ntshav calcium concentrations tsis cuam tshuam los ntawm .Nyob rau hauv physiological pH ntau, yog ib qho ionised compound (pKa = 8.6) uas nws kev cuam tshuam nrog calcium channel receptors yog tus cwj pwm los ntawm kev nce qib ntawm receptor binding site conjugation thiab dissociation, thiab cov txheej txheem kev nce qib no ua rau muaj qhov pib tshwm sim.
yog peripheral arterial vasodilator uas ua ncaj qha rau vascular du nqaij, ua rau txo qis peripheral vascular tsis kam thiab txo cov ntshav siab.Lub tswv yim meej los ntawm kev txo qis angina tsis nkag siab tag nrho, tab sis xav tias suav nrog cov hauv qab no: Exertional angina: Hauv cov neeg mob uas muaj exertional angina, NORVASC txo tag nrho cov peripheral tsis kam (tom qab load) thaum lub plawv ua hauj lwm ntawm ib theem ntawm kev tawm dag zog thiab txo tus nqi. Cov khoom siv siab, yog li txo qis myocardial oxygen xav tau.
Thaum pib, 5mg ib zaug ib hnub, nce mus rau qhov siab tshaj plaws ntawm 10mg ib hnub.
