CAS Naj Npawb: 147403-03-0 Molecular Formula: C24H29N5O3
| Melting Point | 230 ° C |
| Qhov ntom | 1.41 g / cm³ |
| cia temp | 2-8 ℃ |
| solubility | Nws yuav luag insoluble hauv dej, thiab solubility hauv ethanol yog 5.5 mg / m |
| kev ua haujlwm kho qhov muag | +76.5 ℃ (C = 1, ethanol) |
| Qhov tshwm sim | dawb los yog dawb dawb, tsis muaj ntxhiab tsw |
yog ib qho uas tsis yog peptide, qhov ncauj zoo angiotensin II (AT) receptor antagonist.Nws muaj kev xaiv siab rau hom I receptor (AT1) thiab tuaj yeem sib tw antagonized yam tsis muaj kev cuam tshuam.Nws tseem tuaj yeem cuam tshuam AT1 receptor mediated aldosterol tso tawm los ntawm adrenal glomerular hlwb, tab sis tsis muaj kev cuam tshuam rau cov tshuaj potassium induced tso tawm, qhia nws cov kev xaiv ntawm AT1 receptors.Hauv vivo thwmsim ntawm ntau hom kev kub siab tsiaj cov qauv tau pom tias muaj cov nyhuv antihypertensive zoo thiab tsis muaj kev cuam tshuam loj rau lub plawv contractile muaj nuj nqi thiab lub plawv dhia.Tsis muaj cov nyhuv antihypertensive rau cov tsiaj uas muaj ntshav siab
Antihypertensive tshuaj.yog angiotensin II (Ang II) receptor antagonist uas xaiv los thaiv kev khi ntawm Ang II rau AT1 receptors (nws cov kev cuam tshuam tshwj xeeb ntawm AT1 receptors yog li 20000 npaug ntau dua li ntawm AT2), yog li inhibiting vascular contraction thiab aldosterone tso tawm, ua rau cov teebmeem hypotensive
Qhov pom zoo pib koob tshuaj rau cov ntsiav tshuaj yog 80mg (2 ntsiav tshuaj), noj ib hnub ib zaug.Feem ntau, yog tias tsis muaj txiaj ntsig rau 4 lub lis piam, qhov koob tshuaj tuaj yeem nce mus rau 160mg (4 ntsiav tshuaj) ib hnub ib zaug.Raws li cov ntaub ntawv kho mob txawv teb chaws, cov koob tshuaj ntau tshaj plaws tuaj yeem ncav cuag 320mg (8 ntsiav tshuaj) ib hnub ib zaug.
1. Cov neeg mob ntshav siab nyuaj nrog ntshav qab zib, ntshav siab nyuaj nrog nephropathy lossis yooj yim ntshav qab zib nephropathy,
2. Cov neeg mob ntshav siab nyuaj nrog lub plawv tsis ua haujlwm lossis myocardial infarction
