CAS Naj Npawb: 330784-47-9 Molecular Formula: C23H26ClN7O3

Cov khoom

CAS Naj Npawb: 330784-47-9 Molecular Formula: C23H26ClN7O3

Lus piav qhia luv luv:

CAS Nr .: 330784-47-9

Lub npe tshuaj:

Cov roj formula: C23H26ClN7O3

Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinyl)carbamoyl]pyrimidine

4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide


Product Detail

Khoom cim npe

Khoom Specification

Melting Point 150-152 ° C
Qhov ntom 1.372 ib
cia temp Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C
solubility DMSO (me ntsis), Methanol (me ntsis, Kub)
kev ua haujlwm kho qhov muag N/A
Qhov tshwm sim Dawb rau Off-White
Purity ≥98%

pharmacodynamics

(Zepeed) tau pom zoo los ntawm Kaus Lim Kauslim Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv rau kev kho mob erectile kawg (ED) thaum Lub Yim Hli 2011.is ib qho kev xaiv ntau hom 5 phosphodiesterase (PDE5) inhibitor.tau tshaj tawm tias yog tus xaiv PDE5 inhibitor tshaj plaws ntawm kev ua lag luam.Qhov pib ntawm Tmax thiab ib nrab-lub neej kuj txawv ntawm cov lag luam PDE5 inhibitors.Sildenafil muaj Tmaxntawm 1 h thiab ib nrab-lub neej ntawm 3-5 h.Vardenafil zoo ib yam li Tmaxntawm 0.6 h thiab ib nrab-lub neej ntawm 4-6 h.Tadalafil muaj qhov ntev tshaj plaws ib nrab-lub neej ntawm cov tshuaj lag luam nrog ib nrab-lub neej ntawm 17 h.muaj qhov pib nrawm nrawm mus txog Tmaxnyob rau hauv 0.6 h nrog ib nrab-lub neej ntawm 1.2 h.Ib qho kev sib txuas ntawm (TA-1790) tau piav qhia hauv cov ntaub ntawv patent.Txoj kev tshem tawm tseem ceeb yog los ntawm cov kua tsib thiab quav.Nws kuj tseem pom tau tias yuav rov ua dua los ntawm enterohepatic recirculation.

siv

Ib qho phosphodiesterase (PDE5) inhibitor, siv los kho erectile kawg.

kev siv thiab ntau npaum li cas

yog ib qho kev xaiv PDE5 inhibitor nrog IC50 ntawm 1 nM.

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