l Cas naj npawb: 171596-29-5 Molecular Formula: C₂₂H₁₉N₃O₄
| Melting Point | > 193 ° C |
| Qhov ntom | DMF: 25 mg/ml DMF: PBS (pH 7.2) (1: 1): 0.5 mg/ml DMSO: 20 mg/ml |
| cia temp | -20 ° C |
| solubility | DMF: 25 mg/ml DMF: PBS (pH 7.2) (1: 1): 0.5 mg/ml DMSO: 20 mg/ml |
| kev ua haujlwm kho qhov muag | [α]/D +68 txog +78°, c = 1 in chloroform-d |
| Qhov tshwm sim | Dawb rau Off-White Khoom |
| Purity | ≥98% |
(lub npe lag luam lossis ) yog ib hom PDE5 inhibitor siv rau kev kho mob ntawm erectile kawg, benign prostatic hypertrophy thiab pulmonary arterial hypertension.Cov nyhuv ntawm yog relaxing cov hlab ntsha cov leeg thiab ua rau cov ntshav ntws mus rau hauv lub corpus cavernosum.Cov txheej txheem ntawm kev ua ntawm yog los ntawm inhibiting cov kev ua ntawm cGMP tshwj xeeb phosphodiesterase hom 5 (PDE5).PDE5 degrades cGMP nyob rau hauv lub corpus cavernosum nyob ib ncig ntawm noov.Yog li ntawd, tadalafi ua rau muaj kev nce siab ntawm cGMP uas ntxiv ua rau cov leeg du thiab nce ntshav ntws mus rau hauv corpus cavernosum.Qee qhov kev tshawb fawb soj ntsuam kuj tau hais tias tuaj yeem txhim kho endothelia muaj nuj nqi hauv cov txiv neej uas muaj kev pheej hmoo siab plawv thiab txo qis cov tsos mob ntawm cov zis thib ob rau benign prostatic hyperplasia.
analgesic, uptake blocker, mu-opiod receptor agonist.Ib qho phosphodiesterase 5 inhibitor.yog siv rau kev kho mob ntawm erectile kawg.
Nws txawv ntawm cov qauv ntawm sildenafil thiab vardenafil.Nws yog absorbed sai heev thiab peaks nyob rau hauv concentration (378 μg / L tom qab ib koob tshuaj 20-mg) tom qab 2 teev, displaying ib nrab-lub neej ntev ntawm 17.5 teev.Nws kuj yog metabolized los ntawm daim siab (CYP3A4).Tshwj xeeb tshaj yog, nws cov tshuaj pharmacokinetics tsis raug cuam tshuam los ntawm kev haus dej cawv lossis kev noj zaub mov lossis los ntawm yam xws li ntshav qab zib lossis mob siab lossis lub raum ua haujlwm.
