CAS Naj Npawb: 224785-91-5 Molecular Formula: C23H33ClN6O4S

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CAS nr: 224785-91-5

Lub npe tshuaj:

Cov ntsiab lus: HCL; Vardenafi; Nuviva; fafinafei; Valdenafil; Levitra, Valdenafil;USP/EP/BP; Levitra, Valdenafil.HCl;224785-91-5;

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Product Detail

Khoom cim npe

Khoom Specification

Melting Point	214-216 ° C
Qhov ntom	N/A
cia temp	Inert huab cua, 2-8 ° C
solubility	N/A
kev ua haujlwm kho qhov muag	N/A
Qhov tshwm sim	Dawb rau Off-White Cyrstalline
Purity	≥98%

pharmacodynamics

yog tus neeg sawv cev thib ob uas yuav tsum tau ua lag luam thiab muaj qhov zoo dua tias nws lub sijhawm pib tsis raug txo los ntawm kev noj cov tshuaj ntawm lub plab tas.Nws yog 30 npaug ntau lub zog ua tus inhibitor ntawm PDE5 (txhais tau tias IC50, 3.9 nM) dua li sildenafil thiab 10 npaug ntau dua li tadalafil, nrog rau kev xaiv ntau dua (> 1,000 zaug) rau tib neeg PDE5 dua li tib neeg PDE2, PDE3, thiab PDE4 thiab nruab nrab xaiv (> 80 zaug) rau PDE1.PDE inhibitory selectivity thiab ob qho tib si hauv vitro thiab hauv vivo potency ntawm PDE5 inhibitor tshiab.tshwj xeeb inhibited hydrolysis ntawm cGMP los ntawm PDE5, nrog IC50 ntawm 0.7 nM (sildenafil 6.6 nM).IC50 ntawm rau PDE1 yog 180 nM, rau PDE6 11 nM, thiab rau PDE2, PDE3 thiab PDE4 ntau tshaj 1,000 nM.